Spravato® (Esketamine) Nasal Spray – 28mg, 56mg, 84mg

What is SPRAVATO and how does it work?

SPRAVATO is a FDA-approved nasal spray prescription medication, use along with an antidepressant, take by mouth to treat treatment- resistant depression (TRD).

Most commonly used oral antidepressants, I thought to treat depression by increasing levels of neurotransmitters (serotonin, norepinephrine, and dopamine) in area of the brain that affect mood. SPRAVATO targets N – methyl – D aspartate (NMDA) receptor and is believed to work differently than currently available or anti-depressants. The exact way it works is unknown.

Who can benefit from Spravato (Esketamine)?

If you have tried and failed one or more antidepressants either due to it not worked or stopping due to intolerable side effects, Spravato may be for you. One our initial consultation we will prescreen you to see if you are a candidate.

Spravato (Nasal Esketamine) FAQ

1. 1. What to expect during treatment?SPRAVATO (Nasal Esketamine) CIII nasal spray must be administered under the supervision of a healthcare provider at a treatment center that is certified in this SPRAVATO Risk Evaluation and Mitigation Strategy (REMS) program. Our Mansfield office is a certified center.After SPRAVATO administration you will rest in a recliner for two hours on-site in a secluded area. During this monitoring, vital signs will be taken periodically, and you will be assessed for other side effects to include dissociation.
   2. Is Spravato approved for use in children or adolescents?No, Spravato is only approved for use in ages 18 or older.
   3. Is Spravato safe for use in pregnancy or breastfeeding?No, Spravato is not known to be safe for use in pregnancy or breastfeeding.
   4. How often will I need to come for the treatments?Twice a week for the first 4 weeks, followed by once a week. Our healthcare provider will determine your frequency after the first two months are completed. This will depend on your response. Prepare to be on-site for 2 hours each visit. Some patients will remain on Spravato as a part of their maintenance medication just as you would on an oral antidepressant.
   5. Can I drive right after SPRAVATO?As SPRAVATO may cause sedation and other side effects that may cause impairment of operating heavy machinery, you must pre-arrange for a ride after each visit. This includes rideshare or a trusted family member, caretaker or friend 18 years or older with a valid driver’s license. This will be your responsibility to ensure this individual meets this criteria.

1. Can I take SPRAVATO if I have epilepsy or seizures?Unlike other neuromodulation treatments such as TMS (transcranial magnetic stimulation), epilepsy or seizures is NOT a contraindication. You may likely be use Spravato. Our healthcare provider will determine this based on your medical history.
2. What are some side effects of Spravato?Most commonly patients report sleepiness (sedation) which is why you cannot drive yourself from the office. Some other side effects may include dizziness, fainting, spinning sensation, feeling disconnected from yourself or anxiety. Please review important safety information for more details
3. What were clinical trial results that supported Spravato was effective?In a short term clinical trial of adults with treatment-resistant depression, those who took Spravato and an oral antidepressant experienced a greater reduction in depressive symptoms at four weeks compared to those who received a placebo and an oral depressant.In a long term study after 16 weeks of therapy, patients who stayed on Spravato were less likely to experience a return of depressive symptoms than those who stopped therapy.
   

   Administration Instructions

   SPRAVATO is for nasal use only. The nasal spray device delivers a total of 28 mg of esketamine. To prevent loss of medication, do not prime the device before use. Use 2 devices (for a 56 mg dose) or 3 devices (for an 84 mg dose), with a 5-minute rest between use of each device. Follow these administration instructions and read the Instructions for Use before administration:

   

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   You may or may not take Spravato long term. This will depend on the condition you are taking Spravato to treat and how your body responds to the drug. Talk with your doctor about whether Spravato is a good long-term treatment option for you.